EVALUATION OF BREED EFFECT ON GENE EXPRESSION OF ARYL HYDROCARBON RECEPTOR (AHR), CYTOCHROME P450 (CYP1A1) AND INTERLEUKINS (IL2) IN CHICKENS REARED IN A CRUDE OIL-POLLUTED ENVIRONMENT

Authors

  • A. Ibrahim Rivers State University, Nkpolu-Oroworukwo, Rivers State, Nigeria
  • O. C. Emeka Federal University of Technology, Owerri, Imo State
  • V. U. Oleforuh-Okoleh Rivers State University, Nkpolu-Oroworukwo, Rivers State, Nigeria
  • A. B. Sikiru Federal University of Agriculture, Zuru, Kebbi State, Nigeria
  • L. B. Fakae Rivers State University, Nkpolu-Oroworukwo, Rivers State, Nigeria
  • U. E. Obianwuna Chinese Academy of Agricultural Sciences, Beijing 100081
  • B. S Nnam Rivers State University, Nkpolu-Oroworukwo, Rivers State, Nigeria

DOI:

https://doi.org/10.51791/njap.vi.4337

Keywords:

aryl hydrocarbon receptor, cytochrome p450, chickens, interleukins, hydrocarbon pollution, oxidative stress biomarkers

Abstract

Hydrocarbon toxicity resulting from the disruption of homeostasis caused by exposure to hydrocarbon pollutants is a significant obstacle that could impede the expression of the full genetic potentials of chicken breeds in the Niger Delta. Depending on the population, the mechanism and severity of toxicity may vary with the level of expression of certain genes modulated by xenobiotics. This study investigated breed effects on expression of aryl hydrocarbon receptor (AhR), cytochrome p450 (CYP1A1) and interleukins (IL2) in chickens. For the investigation, two breeds of chicken: (Nigerian
native chickens and commercial line broiler chickens) raised under extensive system by rural smallholder farmers in Okrika and Nsukka Local government Areas, Rivers and Enugu States, Nigeria were utilized. Liver tissue was excised from individual bird (27 birds per breed) for RNA extraction and gene expression studies. Results revealed that there was significant breed effect in the response of chickens in Okrika where the expression of AhR, CYP1A1 and IL-2 genes was upregulated in the native chickens (p<0.05). Such disparities were not observed in chickens reared in Nsukka. This could
be an indication of increased metabolism and detoxification of hydrocarbon pollutants in the native chicken particularly in hydrocarbon polluted environment. We therefore propose studies on AhR, CYP1A1 and IL-2 as molecular markers for evaluating hydrocarbon toxicity in chickens and possible selection for genetic improvement.

Author Biographies

A. Ibrahim, Rivers State University, Nkpolu-Oroworukwo, Rivers State, Nigeria

Department of Animal Science

O. C. Emeka, Federal University of Technology, Owerri, Imo State

Department of Animal Science

V. U. Oleforuh-Okoleh, Rivers State University, Nkpolu-Oroworukwo, Rivers State, Nigeria

Department of Animal Science

A. B. Sikiru, Federal University of Agriculture, Zuru, Kebbi State, Nigeria

*
Department of Animal Science

L. B. Fakae, Rivers State University, Nkpolu-Oroworukwo, Rivers State, Nigeria

Department of Animal Science

U. E. Obianwuna, Chinese Academy of Agricultural Sciences, Beijing 100081

Insititute of Feed Research

B. S Nnam, Rivers State University, Nkpolu-Oroworukwo, Rivers State, Nigeria

Department of Animal Science

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Published

2024-09-10

How to Cite

Ibrahim, A., Emeka, O. C., Oleforuh-Okoleh, V. U., Sikiru, A. B., Fakae, L. B., Obianwuna, U. E., & Nnam, B. S. (2024). EVALUATION OF BREED EFFECT ON GENE EXPRESSION OF ARYL HYDROCARBON RECEPTOR (AHR), CYTOCHROME P450 (CYP1A1) AND INTERLEUKINS (IL2) IN CHICKENS REARED IN A CRUDE OIL-POLLUTED ENVIRONMENT. Nigerian Journal of Animal Production, 166–169. https://doi.org/10.51791/njap.vi.4337

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