ANTHELMINTIC EFFECT OF AQUEOUS EXTRACT OF ANOGEISSUS LEIOCARPUS STEM-BARK ON THE EGGS OF HAEMONCHUS CONTORTUS OF SHEEP

S. F Yahaya; P. L.  Kobo; A. M.  Tauheed; P. O.  Yusuf; H.  Aliyu - Amoo; M.  Shittu; D.  Sani; M. M.  Suleiman; M.  Mamman

doi:10.51791/njap.vi.6178

Authors

S. F Yahaya Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria.
P. L. Kobo Ahmadu Bello University, Zaria.
A. M. Tauheed Ahmadu Bello University, Zaria
P. O. Yusuf Ahmadu Bello University, Zaria
H. Aliyu - Amoo Ahmadu Bello University, Zaria
M. Shittu Ahmadu Bello University, Zaria
D. Sani Ahmadu Bello University, Zaria
M. M. Suleiman Ahmadu Bello University, Zaria
M. Mamman Ahmadu Bello University, Zaria

DOI:

https://doi.org/10.51791/njap.vi.6178

Keywords:

Anthelmintic, stem-bark, Anogeissus leiocarpus, Haemonchus contortus, eggs

Abstract

Haemonchus contortus (H. contortus) is a very important gastro intestinal nematode that has been recognised as one of the most significant causes of anaemia in small ruminants in many countries of the world. The main method of control for H. contortus has been the use of anthelmintics. However, due to continuous and inappropriate use of these drugs, it has resulted in the loss of their effectiveness and the development of anthelmintic resistance. Anogeissus leiocarpus aqueous stem-bark extract (AAE) was investigated for its egg hatch inhibitory activity against H. contortus. The extract was prepared by cold maceration and five different concentrations of the extract were studied (4 mg/ml, 2 mg/ml, 1 mg/ml, 0.5 mg/ml and 0.25 mg/ml). Albendazole and distilled water were used as positive and negative control respectively. The IC50 of AAE for the egg hatch assay was 1.48 mg/ml. Increasing concentrations of the extract exhibited increasing activity up to 2 mg/ml, after which the activity started to decrease. Anogeissus leiocarpus (A. leiocarpus) could find application in the treatment of H. contortus infection in ruminants.