Experimental trypanosomosis in two breeds of Nigeria goats: Changes in haematology, total proteins and serum glucose after treatment with a brand of trypanocide

Abstract

An investigation on the effects of experimental Trypanosoma congolense infection on the changes in some haematological parameters, total serum proteins and serum glucose levels in Red Sokoto (RS) and West African Dwarf (WAD) breeds of goats after treatment with a brand of trypanocide is reported. Thirty goats comprising 20 does and 10 bucks of West African Dwarf and Red Sokoto breeds were used in the experiment. Each doe (10 in each group) was infected with ImLx 10 of Trypanosoma congolense (Karu strain) over a period of eight weeks. Randox kir (Randax lab, USA) was used to determine serum glucose levels the local serum proteins were determined using the Bure method while Wood cell indices were determined using pocH-100iV Diff (Sysmex Animal health, Germany). Data obtained from the study were statistically analyzed using Chi-square test and Student's l-lest. On day nine post-infection, the serum glucose levels of the infected goals were significantly (p0.05) lower than those of the non-infected ones (97.8±6.5 and 28.3±17.6 mg/dl SEM for RS and WAD gouts, respectively). Also, the serum proteins of the infected goals were significantly (p<0.05) lower than those of the non-infected ones (3.4±0.5 and 3.8±0.3 mg/dl SEM for RS and WAD goats respectively) and there was severe anaemia in the two breeds of goats. The return of serum glucose levels and the serum protein values to normal was faster in the WAD goats and the anaemia in the two breeds of goats was reversed following treatment with Dimnazene aceturate (Samoreni Alfasan Holland). Therefore, trypanosome infection in Red Sokoto goats can be more severe. In conclusion, hypoglycemic and hypoproteinemic effects of trypanosomosis with severe anaemia in goats can be reversed with an intervention with trypanocides