THE EFFECTS OF EUGLVCEMIC INSULIN CLAMP ON THE METABOLISM OF 3-HYDROXVBUTYRATE AND PLASMA FREE FAHY ACIDS BY THE HIND LIMB OF LACRATING SHEEP

Authors

  • A. J. A OSUAGWUH University of Newcastle Upon Tyne NE1 7RU England
  • R. R. SMITHARD University of Newcastle Upon Tyne NE1 7RU England
  • J. METCALFE University of Newcastle Upon Tyne NE1 7RU England
  • T. E. C. WEEKES University of Newcastle Upon Tyne NE1 7RU England

DOI:

https://doi.org/10.51791/njap.v15i.965

Keywords:

Euglycemic insulin clamp, Metabolism, 3- hydroxybutyrate plasma free fatty acids, Lactating sheep

Abstract

The effects of exogenous insulin, with euglycemia, on the concentration differences, extraction ratio and uptake of 3- hydroxybutyrate and plasma free fatty acids by the lactating sheep hind limb were studied. Generally, the results showed that with increasing plasma insulin levels, while maintaining euglycemia, the concentrations, arterio-venous concentration differences, extraction ratio and uptake of 3-hydrubutyrate and free fatty acids Were significantly (P<0.05) reduced, but Significant correlation was established between arterial concentration of 3-hydtoxvbutyrate and plasma free fatty acids and their uptake. A similar relationship was also obtained between the arterial concentrations of 3-hydroxybutyrate plasma free fatty acids.

Author Biographies

A. J. A OSUAGWUH, University of Newcastle Upon Tyne NE1 7RU England

Department of Agriculture Biochemistry and Nutrition

R. R. SMITHARD, University of Newcastle Upon Tyne NE1 7RU England

Department of Agriculture Biochemistry and Nutrition

J. METCALFE, University of Newcastle Upon Tyne NE1 7RU England

Department of Agriculture Biochemistry and Nutrition

T. E. C. WEEKES, University of Newcastle Upon Tyne NE1 7RU England

Department of Agriculture Biochemistry and Nutrition

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Published

2021-01-05

How to Cite

OSUAGWUH, A. J. A., SMITHARD, R. R., METCALFE, J., & WEEKES, T. E. C. . (2021). THE EFFECTS OF EUGLVCEMIC INSULIN CLAMP ON THE METABOLISM OF 3-HYDROXVBUTYRATE AND PLASMA FREE FAHY ACIDS BY THE HIND LIMB OF LACRATING SHEEP. Nigerian Journal of Animal Production, 15, 63–69. https://doi.org/10.51791/njap.v15i.965

Issue

Vol. 15 (1988)

Section

Articles

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