EFFECTS OF BERENIL ON THE PATHOGENESIS OF TRYPANOSOMIASIS IN Trypanosoma brucei INFECTED RATS

Authors

  • J. S. Rabo Pathology University of Maiduguri P.M.B. 1069, Bono State, Nigeria
  • A. B. Wakil Pathology University of Maiduguri P.M.B. 1069, Bono State, Nigeria
  • H. C. C. Maduka College of Medical Sciences, University of Maiduguri, Nigeria

DOI:

https://doi.org/10.51791/njap.v21i1.1165

Keywords:

Berenil, Trypanosomiasis, Rats

Abstract

Ten Albino rats were each infected intraperitoneally with 0.5 million Trypanosoma strain 8/18 organisms. Cerebral lesions were absent in all rats and mice injected with brain tissue and choroid plexus homogenates from group A rats were aparasitaemic over anobservation period of 30 days. However, infected rats developed intermittent (parasitaemia, lost weight progressively and became anaemic with death intervening in one case. We conclude that T. bricci strain 8/18 infection in rats produces moderate to severe disease which may lead to death; but the organism is is not pushed across the blood-brainbarrier by berenil treatment in the acute stage.

Author Biographies

J. S. Rabo, Pathology University of Maiduguri P.M.B. 1069, Bono State, Nigeria

Department of Veterinary 

A. B. Wakil, Pathology University of Maiduguri P.M.B. 1069, Bono State, Nigeria

Department of Veterinary 

H. C. C. Maduka, College of Medical Sciences, University of Maiduguri, Nigeria

Centre for Toxicological and Drug Metabolism Research, Dept of Biochemistry 

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Published

2021-01-03

How to Cite

Rabo, J. S., Wakil, A. B., & Maduka, H. C. C. (2021). EFFECTS OF BERENIL ON THE PATHOGENESIS OF TRYPANOSOMIASIS IN Trypanosoma brucei INFECTED RATS . Nigerian Journal of Animal Production, 21(1), 142–145. https://doi.org/10.51791/njap.v21i1.1165

Issue

Vol. 21 (1994)

Section

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