COMPARATIVE GENOMICS OF GENE SIOOA8 OF PIG AND ITS PROTEIN PRESCRIPTION WITH OTHER MAMMALS

Abstract

Gene S100A8 is the gene that encodes the Protein SIOO. It is a family of low-molecular-weight protein found in vertebrates and characterized by two calcium-binding sites that have helix-loop-helix conformation. It plays a prominent role in the regulation of inflammatory processes and immune response. The nucleotide and amino acid sequence (AAS) of Gene S100A8 of pig were downloaded from the National Center for Biotechnology information (NCBI) data base, United State of America and Uniprot. The Gene S100 AAS of other species were downloaded from Universal protein resources (Uniprot) database, United Kingdom. Data generated were analyzed by bioinformatics tools. The result shows that the protein structure of 87 residues (98%) modelled at >90% accuracy was obtained. The secondary structure disorder prescription result was 22% disorder, Alpha Helix of 70% and 0% of Beta strand. The evolution relationship of Gene S100A8 of pig and other mammals were highly related and conserved among the mammalian species; they have high comparability and they evolved from common ancestors.