HAEMATOPOEITIC POTENTIALS OF METHANOLIC EXTRACT OF TETRAPLEURA TETRAPTERA PODS IN MALE ALBINO RATS

Abstract

This study was carried out to determine the haematopoietic potential of the methanolic extract of Tetrapleura tetraptera in male albino rats. Twenty five rats weighing between 147 and 166 g were used for the study. Anaemia was induced by daily removal of 2ml of blood per 100g body weight for ten days. Thereafter, the animals were administered with the extract for seven days. The rats were treated with 50mg/kg, 100mg/kg and 200mg/kg respectively for groups A - C while groups D (negative control) and E (positive control) received 5 ml/kg of water. Results showed successful induction of anaemia. There were significant increases in the erythrocytic parameters after administration of the methanoloic extract of T. tetraptera. The concentration dependent increase in the PCV, HBC, RBC, MCH and MCHC in the groups treated with the extract when compared with the untreated groups suggests that the extract possesses some haematopoietic potentials