THE TOXIC EFFECTS OF MULTIPLE DOSES OF DIMINAZENE ACETURATE ON THE HAEMATOLOGICAL VALUES OF RATS.

Résumé

The haematological effects of increasing doses of diminazene aceturate on the blood of swiss albino rats was examined. Following the administration of the drug there was a significant increase in white blood cell (WBC) count (P<0.05). The increase in WBC count occured at all dose levels of 3.5, 7.0), 14.0 and 28.0mg/kg body weight. There was minor change in serum sodium and significant changes in serum potassium levels. All these changes were found not to be strictly dose dependent. This study shows that administration of diminazene aceturate produces increases in white blood cells.