PACKED CELL VOLUME AND ANIMAL INOCULATION STATUS OF Trypanosoma evansi INFECTED WEST AFRICAN DWARF GOATS TREATED WITH ARTEMETHER-LUMEFANTRINE

Abstract

The anaemia and animal inoculation status of West African Dwarf (WAD) goats infected with 0.5 mL inoculum of Trypanosoma evansi (T. evansi) and treated with Artemether-Lumefantrine was investigated. Twelve male goats approximately weighing 7kg were divided into 3 groups with 4 goats each in a completely Randomized Design. The untreated control, Diminazene treatment and Artemether treatment represented groups 1, 2 and 3 respectively. Three (3) male albino mice were used for the animal inoculation technique with the 1st, 2nd and 3rd mouse representing groups 1, 2 and 3 respectively. The PCV and parasitaemia of the goats were subjected to one way ANOVA, while line graphs were used to illustrate variations in parasitaemia of the goats and mice. Results revealed similar (P>0.05) influence across the groups, although anaemia was observed in untreated group 1. Group 3 had the highest PCV values. Parasitaemia of the goats were scanty, the mice of groups 1 and 3 had massive parasitaemia and that of group 2 was not detected because the goats were treated with Diminazene which may have cleared the parasites from its blood stream. Artemether-Lumefantrine at 5 mL dose in group 3 goats was found to be effective in the anaemia management of Surra and animal inoculation showed the inability of the protozoan drug to clear completely the T. evansi from the blood system